(1

(Man)

= I have added some addenda from 2d Edit to my copy =

Medical notes and Reflections by H. Holland M.D

p. 13 unity of creation; strongest argument for – that being able to predicate form — fragment which the whole is

p. 14 it is almost universal law that every monstrosity has its analogy in some inferior animal

p 16 Examples of the animal conformation of particular organs transmitted by descent an alike numerous & familiar — old age being hereditary is curious & fact of same kind.

p. 20 Hydronale occuring out of those of from successive generations; & the infirm depended on being a female — wh however true omitted it. — other case given in Med. Chirug. Transact. Vol. IX p. 363

p 23 one generation sometimes escape hereditary disease in like manner as it does some strongly marked feature

p. 24. several cases of all or several of the children of a family being affected with some disease not common to the parents

[in margin:] (it would be well to look to statistics of disease & then discover how far external agents produce those diseases wh becomes hereditary)

2/

p. 25 At Manchester there were 48 children deaf & dumb taken from 17 families the total number of children in these families being 106, giving on an average of three such cases in one family. — Out of these instances, but one in which the defect was known in the parents.

p. 25 diseases hereditary transmitted to either males or females; cases of this are given Archive Generale Oct 1833 & July 1835.

p. 31 strong tendency to hereditary character in disorders of the brain — have insanity hereditary not only in families, but even "in districts, where from local circumstances there has been little inter mixture with the rest of the world." — From insanity being then hereditary "we gather this important conclusion, that some derivative in physical structure, whether obvious or not in the

[in margin:] My father, effect of [2 words illeg]

3/ of the aberration it presents. In no other way can we conceive the transmission of the tendency from one generation to another." "& therefore of mental peculiarities in Hybrids" quote Dr. Holland.

p. 34 Children of same family are affected [insertion:] (that I may escape ours) by same diseases in some peculiar manner. In twins these coincidences show themselves more remarkably. My father?

and when two children have been very alike each other there has been strong resemblance in the forms of diseases.

These facts infer the children, become extremes causes have not yet much affected them.

p. 35 Of hereditary diseases, there are some which evolve themselves at certain periods not only [gout] & [scrofula]; but even applies to disease affecting particular organs as heart or brain.

p. 36 Disease equally transmitted from father & mother.

4/

Blushing

p. 64 Consciousness directed to particular part or organ of the body produces some effect

p. 65 acts on the heart & on irregular pulsation

p. 66 Yawning, coughing & sneezing instances of actions partly voluntary & involuntary — effects of attention on them well known.

66 Act of swallowing rendered difficult by attention — pills.

p. 67 Feelings of nausea increased by attention to it. action of bowels & bladder much influenced by same cause

p. 67 a peculiar sense of weight will be felt by thinking or a portion even of a limb

p. 68 "In that state of the skin however produced of which a general itching is the symptom, the attention directed upon any particular part, will very often being this sensation immediately to it" thinks some real change is produced in such parts within in their nervous state or circulation

p. 69 attention directed to bodily senses, as hearing &c produces change in them